Abstract
Long non-coding RNAs (lncRNAs) have been extensively studied to participate in the carcinogenesis of various tumors. LncRNA FGD5-AS1 has been studied as an oncogene in several cancers; however, the role it plays in oral squamous cell carcinoma (OSCC) still remains unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess relevant RNAs expression. CCK-8 and colony formation were combined to investigate cell proliferation. Flow cytometry was implemented to test the apoptosis of cell. Wound healing assay and transwell assays were conducted to investigate cell migration and invasion. Western blot assay was conducted to measure relevant protein expression. FGD5-AS1 expression was aberrantly up-regulated in OSCC tissue and cells. FDG5-AS1 up-regulation induced USP21 overexpression advances OSCC development. Knockdown of FGD5-AS1 inhibited cell growth, migration, and invasion, yet promoted apoptosis. FGD5-AS1 regulates OSCC via competitively binding to miR-520b against USP21. It could become a potential diagnostic biomarker for OSCC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
