Abstract
Background lncRNA and microRNA affect the occurrence and development of many diseases, so they are expected to become diagnostic or predictive indicators. But the relationship between lncRNA FGD5-AS1 and miR-130a and the prognosis of chronic periodontitis is still unclear. The purpose of this study is to explore the prognostic value of the two in chronic periodontitis. Objective This study set out to investigate the prognostic value of lncRNA FGD5-AS1 and miR-130a in chronic periodontitis. Methods Eighty-seven patients with chronic periodontitis who visited our hospital from March 2016 to August 2017 were collected as an observation group (OG), and 72 subjects with periodontal health who underwent physical examination at the same time were collected as a control group (CG). The FGD5-AS1 and miR-130a expression levels of subjects in the two groups were compared, and prognosis of 87 patients who were reviewed one year later was counted. The expression levels of patients with different prognoses were compared when they were admitted to our hospital. We drew the ROC curve and explored the prognostic value of FGD5-AS1 and miR-130a. The risk factors for adverse prognosis were analyzed through logistic regression. Results FGD5-AS1 was lowly expressed in patients, while miR-130a was highly expressed. FGD5-AS1 and miR-130a had certain diagnostic and predictive value in chronic periodontitis and patient prognosis. The higher the periodontal pocket, the higher the attachment loss. Lower FGD5-AS1 and higher miR-130a levels were independent prognostic risk factors. Conclusion lncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR-130a is highly expressed. Both of them have certain diagnostic and prognostic value in chronic periodontitis and may be potential diagnostic and prognostic indicators.
Highlights
Periodontitis is the most common inflammatory disease in the world, which affects about 50% of adults and 60% of people over 65 years old
By comparing the Long noncoding RNA (lncRNA) FGD5-AS1 and miR-130a expression levels in both groups, we found that FGD5-AS1 (0:51 ± 0:28) in the observation group (OG) was obviously lower than that in the control group (CG) (1:03 ± 0:45) (t = 8:899, P < 0:001) (P < 0:05), and miR-130a (1:58 ± 0:44 ) in the OG was obviously higher than that in the CG (1:01 ± 0:32) (t = 9:166, P < 0:001) (P < 0:05)
The receiver operating characteristic (ROC) curve for diagnosis of chronic periodontitis revealed that the area under the lncRNA FGD5-AS1 curve was 0.835 and the best specificity and sensitivity were 88.51% and 72.22%, respectively, when the cut-off point was 0.805; the area under the miR-130a curve was 0.851 and the best specificity and sensitivity were 80.46% and 77.78%, respectively, when the cut-off point was 1.227; and the area under the joint detection curve was 0.929 and the best specificity and sensitivity were 80.46% and 90.28%, respectively, when the cut-off point was 0.321 (Figure 1, Table 3)
Summary
Periodontitis is the most common inflammatory disease in the world, which affects about 50% of adults and 60% of people over 65 years old It is an oral disease with extremely high morbidity in China [1, 2]. This study set out to investigate the prognostic value of lncRNA FGD5-AS1 and miR-130a in chronic periodontitis. FGD5-AS1 and miR-130a had certain diagnostic and predictive value in chronic periodontitis and patient prognosis. LncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR130a is highly expressed. Both of them have certain diagnostic and prognostic value in chronic periodontitis and may be potential diagnostic and prognostic indicators
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