Abstract
Long non-coding RNAs (lncRNAs) have been suggested to serve vital roles in tumor initiation and progression. However, the expression and underlying mechanisms of lncRNA FBXL19-AS1 in breast cancer (BC) remain unclear. In the present study, we found that FBXL19-AS1 expression was significantly up-regulated and correlated with advanced clinical features and poor overall survival of BC patients. Functionally, FBXL19-AS1 inhibition suppressed BC cells proliferation, invasion, and epithelial–mesenchymal transition (EMT) processes in vitro and reduced tumor growth in vivo. In addition, we found that FBXL19-AS1 might function as a ceRNA to sponge miR-718, and miR-718 could rescue the effects of FBXL19-AS1 on BC cells progression. Therefore, these findings suggested that FBXL19-AS1 might serve as an oncogenic lncRNA and promoted BC progression by sponging miR-718, indicating FBXL19-AS1 could serve as a potential therapeutic target for BC treatment.
Highlights
Breast cancer (BC) is one of the most commonly occurring female malignant tumors, with an increased incidence and much younger onset age recently [1,2]
QRT-PCR showed that FBXL19-AS1 expression was significantly up-regulated in BC tissues compared with adjacent normal tissues (ANT) (Figure 1A; P
High FBXL19-AS1 expression was associated with BC patients with lymphnode metastasis (LM) and advanced TNM stage (II + III) (Figure 1B,C; P
Summary
Breast cancer (BC) is one of the most commonly occurring female malignant tumors, with an increased incidence and much younger onset age recently [1,2]. Despite noteworthy advances in screening, surgery, and chemo-radiotherapy techniques, the prognosis of BC patients remains unsatisfactory [3,4]. It was of great significance to investigate the mechanisms underlying BC progression. Accumulating evidence reported that lncRNAs play critical roles in various cellular processes, such as cell growth, apoptosis, metastasis, and differentiation [7,8]. Zhang et al [9] revealed that MALAT1 up-regulation correlated with clear cell renal cell carcinoma progression and poor prognosis. Guo et al [10] revealed that SNHG20 could function as an oncogenic lncRNA by regulating miR-140-5p-ADAM10 axis and MEK/ERK signaling pathway in cervical cancer. The roles and underlying mechanism of lncRNAs in tumor progression remain unclear
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
