Abstract
BackgroundLatent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.MethodsParaffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.ResultsElevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients’ overall survival (p = 0.049, p = 0.036).ConclusionLMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.Virtual slideshttp://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899
Highlights
Extranodal NK/T-cell lymphoma, nasal type (ENKTL) is recognized as a distinct clinical pathological entity of non-Hodgkin’s lymphoma, and develops more frequently in East Asia and Central America than in the West [1,2]
The ability of LMP2A to influence the balance of survival factors in B lymphocytes could be functionally important in Burkitt lymphoma and LMP2A expression in Epstein-Barr virus (EBV)-infected B cells may lead to the induction and maintenance of an activated, proliferative state that could result in the development of Hodgkin lymphoma [19,20]
Our results suggest that LMP1 and LMP2A are potential biomarkers for the diagnosis and prognosis of patients with ENKTL
Summary
Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed. Results: Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients’ overall survival (p = 0.049, p = 0.036). Conclusion: LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL
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