Abstract
Hepatocellular carcinoma is the most common and deadliest form of primary liver tumors with limited treatment options. Immunotherapy is a rising promising treatment in recent years. An attenuated hepatocellular carcinoma-specific Listeria vaccine (Lmdd- MPFG, LM), constructed by is proven to have potency to induce a strong and specific anti-tumor cellular immunity to HCC [1]. It has been proven that dendritic cells (DCs) play an essential role in Lm infection. In this paper, the researchers elucidated the valuable mechanism how DC initiates and induces anti-HCC immunity by Lmdd-MPFG vaccine
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