Аllogeneic fetal fibroblasts applying in treatment of dermal burns in patients after explosion in coal mines

Abstract

Abstract: Aim Efficiency of use allogeneic fetal fibroblasts in treatment of the burnt miners based on the data of morphological research of a burn wound and clinical results of surgical treatment. For a goal performance morphology features of burn wounds are studied. Material and methods With this purpose were selected 14 miners, affected by explosions of a methane- coal compound in the Donbass mines, who treated in Donetsk Burn Center from 2007 to 2009. The cultures of fetal allofibroblasts were used in treatment of the patients. For the goal solution (clinical efficiency of allofibroblasts culture application) we studied results of surgical treatment of 36 miners which were treated in Burn Center of Institute of Urgent and Reconstructive Surgery after V.K. Gusak from 2004 to 2012. Results According to morphological researches transplantation of allofibroblasts culture at superficial thermal burns allows to achieve 1.7 times quicker formation of epithelial layer in comparison with traditional techniques of local treatment of a burn wound, and also to achieve formation of the granulation tissue. Clinically proven that the use of fetal allogenic fibroblasts culture in the surgical treatment of deep dermal burns, reduced the number of skin grafting 1.57 times. Conclusions Therefore, on the violations of proliferative processes revealed in our research in wounds, at burned with the combined trauma it is possible to influence effectively by means of cellular technologies.