Abstract

A large positive BeAM value (difference between bedtime [Be] and next-day pre-breakfast [AM] glucose) may indicate to physicians when prandial therapy needs to be added and further titration of basal insulin should be ceased. This study explores whether the addition of the GLP-1 receptor agonist lixisenatide (LIXI) has a greater impact than placebo (PBO) on the reduction of BeAM value when added as prandial therapy to basal insulin in type 2 diabetes mellitus (T2DM) patients.

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