Abstract
This chapter discusses the techniques to analyze living cells by means of Surface plasmon resonance (SPR) and SPR imaging (SPRI), and their applications for cell biology and medicine. Surface plasmon resonance (SPR) sensors can sensitively detect refractive index (RI) changes on the sensor surface of sensor chip coated with gold thin film in real-time. As described above, SPRI sensors can visualize RI pattern on the sensor chip coated with gold thin film. Several applications of SPRI sensors for living cell analysis have been reported by other groups. Long-range SPR system with multiple-layered structure for molecule interactions and living cells analysis have also been reported. Zhang et al. proposed a method for simultaneous measurement of RI distribution and cyclic voltammetry using electrochemical-surface plasmon resonance imaging. Real-time and label-free monitoring of living cell conditions and functions are strongly needed in the field of basic research of cell biology and medicine.
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