Abstract

Polarization Sensitive Optical Coherence Tomography (PS-OCT) measures the intensity and polarization state of backscattered light to provide information about tissue structure, retardation and depolarization. Developing molecular contrast agents for PS-OCT could also provide physiological, cellular, and molecular information. In this study, we utilize the depolarization and spectral signature of anisotropic gold nanobipyramids (GNBPs) and demonstrate how the optical properties of these nanostructures can be used as contrast agents for PS-OCT in living tissue.

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