Livestock-associated Methicillin-resistant Staphylococcus aureus as a New Impendence for Public Health

A N Vaganova,V N Verbov,A M Sokurova,S V Borisenko

doi:10.22625/2072-6732-2019-11-4-122-133

A N Vaganova, V N Verbov + Show 2 more

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https://doi.org/10.22625/2072-6732-2019-11-4-122-133

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Abstract

MRSA is the polyphyletic group into Staphylococcus aureus species. In accordance to the hostal preference, this group is divided, to three subgroups, i.e hospital-associated. MRSA, HA-MRSA, which, includes nosocomial staphylococci variants, community-associated MRSA, CA-MRSA, that is related to human environment and livestock-associated MRSA, LA-MRSA, that has zoonotic origin and commonly is associated with livestock. LA-MRSA is widespread in most countries. The serious problem, is the spread, of LA-MRSA carriage in humans that work in closely contact with livestock. Interaction between populations of CA-MRSA and LA-MRSA leads to acquisition, of human pathogenicity-associated, genes in zoonotic MRSA. The variants of LA-MRSA, that can spread between human arises as the result of this process. These staphylococci may be the cause of human diseases, including hospital-acquired, infections. Intensification of animal husbandry determined massive and uncontrollable antibiotic usage and resulted to development and ubiquitous spread of LA-MRSA, that is, in contrast to CA-MRSA, is characterized, by multiple drug resistance. This circumstance make practically impossible to eliminate LA-MRSA in human and livestock environment. In such considerations, monitoring of ecologic, epizootic and epidemiologic situation in human and. livestock becomes one of the main ways to control the spread of MRSA and diseases, associated with it.

Highlights

MRSA is the polyphyletic group into Staphylococcus aureus species
У большинства выделенных на территории этой страны изолятов LA-MRSA, относящихся как к клональному комплексу CC398, распространённому в странах Западной Европы, так и к представленным в Италии клональным комплексам CC97 и CC1, присутствовали гены, ассоциированные с устойчивостью к тетрациклинам, макролидам и аминогликозидам, а также гены, продукты которых являются транспортерами, селективно выводящими из клеток флорфеникол
От того момента, когда не имевшие существенного значения случаи выявления LA-MRSA были единичными, до времени, когда распространение стафилококков данной группы стало представлять проблему для здоровья народонаселения различных регионов, в том числе высокотехногенных стран, прошло всего 40 лет

Summary

Introduction

MRSA is the polyphyletic group into Staphylococcus aureus species. In accordance to the hostal preference, this group is divided to three subgroups, i.e hospital-associated MRSA, HA-MRSA, which includes nosocomial staphylococci variants, community-associated MRSA, CA-MRSA, that is related to human environment and livestock-associated MRSA, LA-MRSA, that has zoonotic origin and commonly is associated with livestock. Стафилококки данной группы, как и LA-MRSA CC398, патогенны для человека. На территории США среди поголовья свиней, а также у здоровых работников свиноводческих комплексов часто выявляются LA-MRSA, относящиеся к клональному комплексу CC5 [19].

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Conclusion