Abstract
SYNOPSIS.Six isomeric amino‐azotoluenes have been fed to different groups of rats and mice, to test the influence of slight changes of chemical structure on carcinogenic activity.Liver damage was produced earlier in mice than rats, but the relative potency of the six isomers was similar for both species. Only two isomers–o: o and o: p‐induced liver tumours in rats and mice, but p: m and m: m were also carcinogenic, in lesser degree, in mice alone.The sequence of histological changes seen in the liver is described and pictured. In rat livers perilobular necrosis was succeeded by regeneration in the necrotic areas with microscopic hepatoma formation at some of these sites, culminating in malignant hepatoma or, occasionally, cholangioma. In mouse livers no preliminary necrosis occurred, but irregularities in cellular pattern and size of nuclei were followed by microscopic hepatoma or pronounced proliferation of bile ducts, with the final emergence of malignant hepatoma or cholangioma, or both.
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