Abstract
Because of reasonable evidence that contraceptive steroids are involved in the sudden increase of benign liver tumors in young women a registry of liver tumors was initiated at the University of Louisville in late 1973 to provide a source of clinical and pathologic data and drug association. Patients with benign tumors varied in age from 14 to 47 years; the average age was 29.8 years. The women tended to be long-term users; the length of exposure ranged from 4 to 156 months. Attempts to produce liver tumors in young female mice by feeding contraceptive steroids over many months have been unsuccessful. The risk of liver tumors in users appears to be very small and should be evaluated in terms of the benefit of the medication.
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