Abstract
Letters19 April 2011Liver Transplantation From Donors With Acute Intermittent PorphyriaJoanna K. Dowman, MBChB(Hons), Bridget K. Gunson, Simon Bramhall, MD, Philip N. Newsome, PhD, and Mike N. Badminton, MBChB, PhDJoanna K. Dowman, MBChB(Hons)From Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom, and Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.Search for more papers by this author, Bridget K. GunsonFrom Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom, and Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.Search for more papers by this author, Simon Bramhall, MDFrom Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom, and Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.Search for more papers by this author, Philip N. Newsome, PhDFrom Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom, and Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.Search for more papers by this author, and Mike N. Badminton, MBChB, PhDFrom Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom, and Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-8-201104190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Acute intermittent porphyria (AIP) results from partial deficiency of the enzyme porphobilinogen deaminase (1). The clinical disease includes life-threatening neurovisceral attacks from neuronal damage. The cause of these attacks has not been established but involves the heme precursor δ-aminolevulinic acid (ALA) (2). The liver is the major source of excess ALA production, and transplanting a normal liver into a patient with AIP effectively resolves this disease (3).Because clinical expression of AIP is more common in premenopausal women, we hypothesized that a liver removed from a premenopausal woman who is receiving a normal liver allograft could safely be transplanted ...
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