Liver transplantation for advanced hepatocellular carcinoma in patients with Child-Pugh A and B.

Abstract

To investigate the outcomes of living donor liver transplantation for advanced hepatocellular carcinoma in Child-Pugh A/B patients and the usefulness of our expanded selection criteria, the Kyoto criteria. A total of 82 recipients with a Child-Pugh class A (n=27) or B (n=55) status having either multiple hepatic nodules or solitary tumors ≥5cm in size treated between February 1999 and August 2012 were enrolled in this study. The overall recurrence rate was significantly less for the Child-Pugh B patients than for the Child-Pugh A patients (P=0.042), while the survival rates did not differ. In the Child-Pugh A and B patients, the survival rate was significantly greater, while the recurrence rate was lower among the patients meeting the Kyoto criteria than those exceeding these criteria (P=0.006, P=0.001, P=0.032 and P<0.001, respectively). In the Child-Pugh B patients, the overall survival and recurrence rates did not differ between the patients treated with and without pretreatment for hepatocellular carcinoma. In the Child-Pugh B patients treated with pretreatment, the overall survival rate was significantly greater, while the recurrence rate was lower among the patients meeting the Kyoto criteria than those exceeding these criteria (P<0.001, P<0.001, respectively). Living donor liver transplantation performed within the Kyoto criteria achieves excellent overall survival and recurrence rates, especially for Child-Pugh B patients, even those with advanced hepatocellular carcinoma.