Liver Transplantation and Concomitant Prostate Cancer: Is it Feasible?

Abstract

Nowadays liver transplantation is the standard treatment for chronic and acute liver failure with excellent patient and graft survival rates which both have improved through the years Liver transplant LT candidates must undergo a specific and thorough transplant evaluation including several tests and screening for extra hepatic malignancies Screening for prostate cancer is recommended in all male candidates older than years Although LT is precluded in candidates with concomitant neoplasms other than biliary or liver early prostate cancer has very good outcomes with curative treatments However international guidelines contraindicate LT in patients with extrahepatic malignancies We therefore report a case of years old male with primary biliary cholangitis PBC who underwent a first LT in The patient latter developed progressive renal failure and loss of liver graft due to PBC recurrence He was then evaluated for simultaneous liver kidney SLK transplantation During screening tests he was diagnosed with non invasive prostate adenocarcinoma with no metastatic lesions Stage II Balancing risks and benefits before transplant we decided to avoid prostatectomy and treat the patient with hormonal therapy Goserelin The patient underwent SKL transplantation successfully continued with hormonal therapy and received local radiotherapy the first year after transplant without complications We report here a unique case of combined liver and renal transplant with active prostate cancer who received only hormonal therapy before transplantation with absence of progression while on immunosuppression nbsp