LIVER TRANSAMINASES AND PLATELET COUNT CORRELATION IN DENGUE PATIENTS FROM TERTIARY CARE HOSPITAL

Abstract

Background: Dengue is the arboviral febrile illness, which affects the vascular, muscular, and hematological systems. One of the standards used by WHO recommendations as a possible predictor of the clinical severity of infection is thrombocytopenia. A well-known aspect of dengue illness that is accompanied by hepatomegaly and elevated serum transaminase levels is hepatic dysfunction. This study's objective was to determine the liver's con Objective: tribution to dengue infection during the severity of dengue infection by comparing platelet counts and liver transaminase enzyme levels in a tertiary care facility. Admitted cases of Dengue fever (dengue serology positive –IgM) Method: were divided into 3 groups: DF, DHF, DSS based on the clinical and laboratory finding and relation of aminotransferases level were analyzed. Elevation in LFTs were co-related with DF, DHF, DSS. Result: In DF there was 7% patients having mild platelets and 93% patients having moderate platelets. In DHF, 7.4% patients had mild platelets, 70.4% having moderate and 22.2% had severe platelets. In DSS 79.3% patients had moderate platelets and 20.7% had severe platelets. The association was found significant. Transaminase levels rise in nearly all dengue cases, according t Conclusion: o our study's findings. Since AST and ALT levels are negatively correlated, an increase in dengue severity is accompanied by an increase in AST and ALT levels, and decrease in platelet count.