Abstract
Liver regeneration is a highly organized tissue regrowth process and is the most important reaction of the injured liver. The present study endeavors towards the preparation and characterization of nanoporous Sodium Alginate (SA)/ Poly Vinyl Alcohol (PVA) composite, nanofibrous scaffolds coated with silver (Ag) nanoparticles for hepatocellular regeneration. Chitosan based Silver nanoparticles possess high antibacterial activity has been preferred in the scaffold preparation to improve the antibacterial properties. The structural characterization of Ag Nanoparticles revealed the amorphous nature with an average particle size of 300 nm. Nanofibres (Scaffolds) were prepared by electrospinning SA/PVA solution at a voltage of 18-25 kV and Ag NPs were coated on it for antibacterial activity. Invitro studies denoted the growth of nitro compounds, amides and collagen which are the major constituents of liver tissue.
Highlights
The liver is metabolically an active organ that requires high oxygen and nutrient
The Amorphous nature of the NPs is inferred by the absence of grain boundary in the SEM image which is supported by the lack of sharp crystalline peaks in the XRD pattern
The structural characterization revealed the amorphous nature with an average particle size of 300nm
Summary
The liver is metabolically an active organ that requires high oxygen and nutrient. A healthy liver is only the visceral organ that possesses the capacity to regenerate. The people with liver failure are put to medication or go towards hiring the liver While these methods have their limitations such as effect of steroids & liver transplantation has many consequences and might lead to disease like idiopathic neonatal hepatitis, Cholangio carcinoma, alagilles syndrome (bile duct complication) and at certain cases causes liver rejection after few years of liver transplant which might result in death [1]. These major drawbacks can be overcome by regeneration of liver tissue which is a better alternative for liver transplantation. Development in the field of tissue engineering has to look forward to developing the regeneration capabilities of the host tissues with bioactive scaffolds to overcome the above mentioned limitations
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