Abstract
Background: Fontan-associated liver disease and fibrosis is a well-known long-term consequence in patients with Fontan circulation. It carries an increased risk of liver cirrhosis and thus hepatocellular carcinoma over time. For suitable diagnostics, the liver elastography is a noninvasive, safe, and feasible method to determine liver stiffness and the stage of liver fibrosis. Usually, this examination has to be performed in inspiratory hold to optimize the results. The effect of respiration on these results in Fontan patients is, however, unclear. To optimize the implementation for this examination, the effects of breathing maneuvers and food intake on liver stiffness in patients with Fontan circulation were investigated.
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