Liver repair of NAFLD patients following effortless exercise and the possible involvement of endogenous stem cells

Abstract

Adipose tissue derived stem cells differentiate into mesenchymal stem cells (MSCs) and hepatocytes which are involved in anti-inflammatory, reparatory, and detoxification processes reinstating liver function. Aerobic, resistance and effortless workouts have been proven to be beneficial for patients with NAFLD, possibly due to stem cells released into the bloodstream from metabolized fat during exercise induced natural lipolysis. We analysed the serum levels of a number of variables such as ALT, AST, ALP, albumin, creatinine, bilirubin, triglycerides and CRP to determine if effortless exercise would demonstrate an improvement of the NAFLD condition that is substantially equivalent to liver repair documented after administering exogenous MSCs injections. We examined 10 prediabetic individuals with NAFLD, 5 males and 5 females 54-64 years of age, who received 15 treatments with an effortless exercise technology, originally invented at London University for obese individuals who have difficulty performing strenuous workouts, as well as those with limited mobility due to age or disease. The hypothesis was that the reduction of triglycerides and visceral adipose tissue (VAT) is accompanied by a natural release of adipose tissue contents into the bloodstream, supplying endogenous MSCs that differentiate into hepatocytes necessary for healthy liver functioning. Results demonstrated a statistically significant improvement of the NAFLD condition in ultrasonography reports along with optimal levels of ALT, AST, ALP, albumin, creatinine, bilirubin and CRP. Additional findings included a notable decrease in triglycerides, VLDL, BMI, VAT, and cortisol, accompanied by an increase in testosterone, BMR, and muscle mass. Our results replicated previous studies which documented a significant repair of hepatic steatosis in ultrasonography reports after using this effortless exercise regimen. The current clinical study strongly suggested the involvement of endogenous MSCs that are vital in organ repair. Reducing VLDL, VAT and triglycerides optimizes health, setting the conditions for the reparative process to commence. The possibility of endogenously released MSCs as a result of an exercise method is a new perspective with very little past research, therefore, more clinical studies focusing on this hypothesis are warranted. Demonstrating the production of endogenous MSCs via an exercise modality will introduce novel treatments for metabolic disorders without the adverse effects often observed after stem cells injections or invasive and trauma based procedures.