Abstract
We determined the change in liver regeneration after partial hepatectomy (PH) in rats treated with buthioninesulfoximine (BSO) or phorone (PHO). BSO administration inhibited the progression of liver regeneration as determined by relative liver weight increase, cyclin D1 and PCNA expression. In rats treated with PHO, however, liver regeneration after PH was enhanced significantly. BSO depressed the elevation of SAM and increased the concentrations of cysteine and its catabolic products, hypotaurine and taurine, in hepatectomized rats. In contrast, hepatic SAM was increased whereas cysteine, hypotaurine and taurine were decreased by PHO treatment. In hepatectomized liver, concentrations of putrescine and spermidine were elevated, but spermine was decreased. BSO administration further increased hepatic putrescine, but decreased spermidine and spermine levels, which were all blocked or reversed in the PHO‐treated rats. GSH‐depleting activities of BSO and PHO in hepatectomized liver were comparable under the conditions used. The results indicate that the progression of liver regeneration after PH is not determined by a change in hepatic GSH level. Altered polyamine levels via a change in hepatic SAM availability may account for the contrasting effects of the two GSH‐depleting agents on liver regeneration.
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