Abstract
In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes.
Highlights
The purpose of our study was to identify features of changes of liver mitochondrial enzyme system in the dynamics of experimental leukemia
We selected and developed benzyl model of leukemia performed by Blair et al [7] in 157 male rats by subcutaneous injection of 40% oil solution of benzyl (0.01 ml per 100 g of body weight) throughout the experiment
Animals with signs of leukemia were sacrificed under Rauschanesthesia, according to the rules outlined by the European Convention for the Protection of Vertebrate Animals (Strasbourg, 1986)
Summary
The purpose of our study was to identify features of changes of liver mitochondrial enzyme system in the dynamics of experimental leukemia. At 6 month after the experiment, activities of SDH, RINADHcytochrome C reductase and succinatecytochrome C reductase were decreased in 3.25 (P
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