Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection

Abstract

The WHO defines pleomorphic liposarcoma as a pleomorphic, high-grade sarcoma containing a variable number of pleomorphic lipoblasts. Pleomorphic liposarcoma represents the rarest subtype of liposarcoma, accounting for approximately 5 % of all liposarcomas and 20 % of pleomorphic sarcomas [1]. Clinically, pleomorphic liposarcoma represents an aggressive neoplasm most often occurring in the limbs of older adults (the lower extremity, particularly the thigh, is the most frequent location) with a peak incidence between the fifth and sixth decade of life. The trunk and the retroperitoneum represent less frequently affected anatomic sites [1].There is an equal sex distribution. Liver as the first and sole site of metastases from a primary extremity softtissue sarcoma is extremely rare [2]. There are only two case reports in English literature with the liver as the first site of spread from an extremity myxoid liposarcoma [3, 4]. To the best of the author's knowledge, there are no case reports of liver metastasis of pleomorphic liposarcoma. There is limited information regarding the appropriate management of these lesions. We report an extremely rare and unusual case of a pleomorphic liposarcoma of the left thigh with hepatic metastasis, treated by liver resection. The patient is well at 3 months after liver resection. Case Report