Abstract
Colorectal cancer is the second cause of death in Spain (20% diagnosed in stage IV), improving survival in recent years thanks to chemotherapy and metastatic surgeries. With regard to a patient diagnosed with native stage IV KRAS colon adenocarcinoma (peritoneal, hepatic), the subject of cytoreduction with HIPEC (intraperitoneal hyperthermic chemotherapy) and the factors that influence the tumor response are reviewed.
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