Abstract
Machine perfusion (MP) is an expanding area of interest in experimental and clinical liver transplantation (LT). Varied technologies and procedures have been reported, and operational standards have yet to be established. We carried out a systematic literature review on use of machine perfusion (MP) in adult liver transplantation (LT) focusing on patients’ characteristics, post-transplant complications, and outcome. The goal of this review was to analyze all clinical studies on MP. We seek to report how many clinical studies on MP existed in literature, what was the MP setting, and results. MP was investigated both as hypothermic and normothermic. Only 2 randomized controlled trials have been found. The reported studies show great heterogeneity in trial endpoints, graft viability criteria, and efficacy parameters, thus underpinning the need for introduction of more accurate taxonomy and identification of more stringent experimental and clinical objectives.
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