Abstract
To test the role of a possible lysosomal defect in the pathogenesis of congenital osteopetrosis, lysosomal morphology and function were investigated in two neonates with the disease. Simultaneously, calcitonin and parathyroid hormone action were studied in the context of a complete mineral balance study. Plasma calcitonin and parathyroid hormone levels were found to be normal, and a target organ response to parathyroid hormone could be demonstrated for the kidney. The presented data suggest that impaired bone resorption in congenital osteopetrosis involves a shift in lysosomal acid phosphatases toward those relatively insensitive to parathyroid hormone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
