Liver involvement in the process of acute respiratory infections in pediatric patients

Nune Baghdasaryan,Gohar Ayvazyan,Nane Mnatsakanyan,Murad Grigoryan,Anush Perikhanyan,Olya Asatryan,Lilit Avetisyan

doi:10.3855/jidc.10914

Nune Baghdasaryan, Gohar Ayvazyan + Show 5 more

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https://doi.org/10.3855/jidc.10914

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Abstract

We aimed to investigate the prevalence of liver involvement in pediatric patients with ARI using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury. A prospective cohort study of 84 armenian children with ARI was conducted to evaluate the associated liver involvement. The diagnostic variables of interest were the signs of clinical disease severity, and enzymatic profile of the patients. Serum levels of OCT were increased in 94% of patients versus routine tests of hepatic panel (AST in 41.7%, ALT in 15.5%, etc). Variance analysis by severity groups showed the serum levels of OCT (p < 0.001), ammonia (p < 0.001), phospholipides (p = 0.05), glucose (p = 0.01), TNF-α (p = 0.01), IL-8 (p < 0.001), AST (p < 0.001), and ALP (p < 0.001) were associated with the severity of underlying disease. Moreover, regression analysis revealed the serum activity of OCT (p value < 0.001, OR = 1.27) and ammonia (p value 0.002, OR = 1.1) significantly predict the severity of the disease. Using more sensitive marker of liver damage can detect more cases of ARI with hepatic manifestations. For evaluation of the liver involvement we are suggesting the testing of serum OCT levels as a more sensitive and specific marker. Pediatric patients with ARI and with higher serum OCT levels have 27% more chance to experience increased disease severity, which can affect on liver state and prolong hospitalization time and cost.

Highlights

We aimed to investigate the prevalence of liver involvement in pediatric patients with Acute respiratory infections (ARI) using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury
The derivatives of lipid peroxidation (LP), necrosis of hepatocytes, TNF-α, IL6, IL-8 are all act as the activators for stellate cells which in turn stimulate the overproduction of connective tissue with the further development of fibrosis
More cases of ARI with hepatic manifestations were detected via OCT than other markers of hepatic injury used in this study

Summary

Introduction

We aimed to investigate the prevalence of liver involvement in pediatric patients with ARI using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury. Results: Serum levels of OCT were increased in 94% of patients versus routine tests of hepatic panel (AST in 41.7%, ALT in 15.5%, etc). Variance analysis by severity groups showed the serum levels of OCT (p < 0.001), ammonia (p < 0.001), phospholipides (p = 0.05), glucose (p = 0.01), TNF-α (p = 0.01), IL-8 (p < 0.001), AST (p < 0.001), and ALP (p < 0.001) were associated with the severity of underlying disease. For evaluation of the liver involvement we are suggesting the testing of serum OCT levels as a more sensitive and specific marker. Pediatric patients with ARI and with higher serum OCT levels have 27% more chance to experience increased disease severity, which can affect on liver state and prolong hospitalization time and cost. The derivatives of lipid peroxidation (LP), necrosis of hepatocytes, TNF-α, IL6, IL-8 are all act as the activators for stellate cells which in turn stimulate the overproduction of connective tissue with the further development of fibrosis

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