Abstract
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. This study was designed to estimate whether liver dysfunction and abnormal ILs could predict the severity of COVID-19. This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. This study may give more exact information to clinicians about the prognosis of patients with COVID-19. In addition, this correlational study between liver disorder and ILs may provide a new vision to diagnosis and treatment in patients.
Highlights
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide and the WHO declared it a pandemic on March 11, 2020 [1]
22 patients developed acute respiratory distress syndrome (ARDS) and 21 patients were admitted to the intensive care unit (ICU), while 19 patients received mechanical ventilation
Hongyan Hou et al found that interleukin-2 receptor (IL-2R) was a significant prognostic factor for patients with COVID-19, which was consistent with this study [12]
Summary
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide and the WHO declared it a pandemic on March 11, 2020 [1]. Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in many previous studies [2, 3]. COVID-19 usually presents with fevers and/or upper and/or lower respiratory symptoms, which may develop into multiorgan failure in severe patients [4]. Liver enzymes are elevated in 14–53% of patients hospitalized with COVID-19. The degree of elevation is usually mild, severe elevations in aminotransferase levels have been reported [5]. Liver dysfunction is vital because elevated liver enzymes may be associated with an increased risk of mortality [6]. The exact mechanism driving COVID-19-related liver injury
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