Abstract

Purpose: Celiac disease is a genetically inherited autoimmune disorder triggered by dietary gluten, that damages the intestinal villi in the proximal small intestine. It may run as apleomorphic condition and misunderstandings about it result in critical delays in diagnosis. “Chronic hepatitis” has a disputable prevalence in celiac disease, but is uncommom as presenting feature in an adult with previously unrecognized celiac disease. Methods: We present a clinical series of 4 cases (3 females, aged 30, 40 and 71, and 1 male aged 22) that presented to the liver outpatient clinic with persistent liver function tests (LFT) abnormalities. Results: We describe their clinical features, endoscopic pattern, histology and serology, and their favourable evolution with LFT normalization after introducing a gluten free diet. Conclusions: We conclude that although intestinal manifestations are considered classical symptoms, liver abnormalities may be the presenting feature and should remind the clinician that a hidden celiac disease has to be sought by appropriate tests and intestinal biopsy.

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