Abstract
Liver function during treatment with an intramuscular progestagen-estrogen combination was assessed in 191 patients. Serum glutamic oxalacetic transaminase and serum glutamic pyruvic transaminase levels did not change significantly. Thymol turbidity determinations and total protein albumin globulin alkaline phosphatase and serum bilirubin levels were all within normal limits. Only 2 patients had deviations from the norm in more than 1 of the battery of liver function studies. Return to normal levels was demonstrated in those individuals with alterations prior to medication. It is concluded however that further long-term follow-up studies of protein fractions and carbohydrate alterations in regard to hepatic changes are warranted.
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