Abstract
During a five-year period, 181 diabetic patients were treated with chlorpropamide at an average dose of 240 mg per day. The cephalin flocculation test (Hanger), serum glutamic oxaloacetic and pyruvic transaminases (SGOT, SGPT), alkaline phosphatase, chemical gamma globulin, serum electrophoretic patterns, leukocyte counts, differential smears, hemoglobin level estimations, complete urinalyses, and blood glucose determinations were used at stipulated intervals to evaluate drug response. Liver function remained normal throughout, except for the cephalin flocculation test which indicated a high incidence of positivity among comparative groups of patients treated with diet alone, insulin treated patients, and an unusually high incidence of positivity among chlorpropamide treated patients. No significant elevations of SGOT, SGPT, or alkaline phosphatase determinations were noted.
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