Liver fibrosis is induced by insulin resistance by enhancing the ductular reaction that undergo epithelial–mesenchymal transition in chronic hepatitis C

G Faraci,L Fabris,G Marchesini,M Cadamuro,E Bugianesi,S Saccomanno,A Benedetti,M Strazzabosco,G Svegliati-Baroni

doi:10.1016/j.dld.2008.12.014

Liver fibrosis is induced by insulin resistance by enhancing the ductular reaction that undergo epithelial–mesenchymal transition in chronic hepatitis C

G Faraci, L Fabris + Show 7 more

https://doi.org/10.1016/j.dld.2008.12.014

Copy DOI

Journal: Digestive and Liver Disease

Publication Date: Mar 1, 2009

Affiliation: Marche Polytechnic University, University of Padua, University of Bologna, University of Bergamo, University of Turin, Yale University

#Hepatic Fibrosis In Chronic Hepatitis #Fibrosis In Chronic Hepatitis + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

Background. The mechanisms for progression of liver injury towards hepatic fibrosis in chronic hepatitis C (HCV) are unknown. Insulin resistance (IR) is an independent predictor of HCV-related fibrosis. A ductular reaction (DR) occurs during chronic liver injury and represents a potential profibrogenic mechanism by the recruitment of myofibroblasts and by undergoing epithelial–mesenchymal transition (EMT).

Full Text