Liver Enzymes Functions Effect of Raphia Hookeri Fruit Pulp (Mesocarp) Extract in Male Wistar Rat’s Model

Abstract

This study is aimed at determining selected liver enzymes functions effect of Raphia Hookeri fruits pulp extract in male wistar rats. A total of 32 apparently healthy rats of weights between 130g and 200g were involved. The rats were segregated into 4 groups, 3 groups administered orally with doses of extract at 500mg/kg, 1000mg/kg and 2000mg/kg body weight while control group fed with feed and water for 28 days. The animals were sacrificed, samples taken, laboratory test done for liver enzymes functions. SPSS version 21.0 (ANOVA) followed by Post-Hoc multiple comparison test used and p< 0.05, values were expressed as SEM for statistical analysis. Results showed AST level of groups 3 and 4 had significant decreases when compared to control and 500mg/kg group respectively. AST level of group 4 was significantly lower compared to that of group 3. ALT level indicated non-significant changes in treated groups when compared to both control and test groups. The ALP levels in groups 2 and 3 showed significantly raised levels of ALP when compared to that of control had significantly reduced level of ALP compared to that of group 2. Increased AST an indication to measure serum ALT to determine whether the increased AST is from liver Willard & twedt, 2012. So the decreased level AST has demonstrated ameliorative effect of the raphia hookeri fruit pulp on hepatic disease and any other disease that causes an increase AST in the body. Regular consumption of this fruit is recommended for those with liver issues.