Liver enzymes Alterations after Laparoscopic Cholecystectomy: A Prospective Study

Abstract

Background: In laparoscopic cholecystectomy, carbon dioxide gas is used for insufflation into peritoneum. The carboxy peritoneum which is used to create space in laparoscopic cholecystectomy is kept at pressure of 10-15mm of Hg. This high carboxy peritoneum pressure is likely to cause impedance in splanchnic perfusion and decrease the hepatic perfusion. This can lead to disturbances in liver functions. Material and Methods: This study was done on a total of fifty patients presenting with symptomatic gall stone disease. Liver function tests were done in all the patients in pre operative and post operative period after laparoscopic cholecystectomy. Results: Total serum bilirubin measured pre operative and post operative were compared, there was no significant change in the serum bilirubin levels. The serum AST levels were compared in preoperative and postoperative period and there was significant increase in level of serum AST. The serum ALT levels comparison between preoperative and postoperative values has shown significant change. The difference in serum alkaline phosphatase levels is also non significant. Conclusion: This study concludes that transient elevation of liver enzymes does occur after laparoscopic cholecystectomy.