Abstract
Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases.
Highlights
The liver is involved in regulation of several major physiological processes, such as glycogen storage, lipid metabolism, plasma protein secretion, and xenobiotic detoxification [1]
This review focuses on hepatic differentiation of liver-derived human mesenchymal stem cell (LHMSC) and their application in liver disorders, opening a new path toward further studies
LHMSCs can differentiate into hepatocyte-like cells, gaining hepatic functions such as production of cytochrome P450, albumin, and urea
Summary
The liver is involved in regulation of several major physiological processes, such as glycogen storage, lipid metabolism, plasma protein secretion, and xenobiotic detoxification [1]. LHMSCs express CD26, albumin, CK8, and CK18, indicating a partial commitment toward hepatic cell differentiation [21, 22, 24]. LHMSCs can differentiate into hepatocyte-like cells, gaining hepatic functions such as production of cytochrome P450, albumin, and urea.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
