Abstract
Liver cytochrome P450-hydroxylation system of tumor-bearing rats under the influence of ω-3 polyunsaturated fatty acids and vitamin D(3)
Highlights
The susceptibility of transformed malignized cells to the action of cytostatics is largely determined by the functional efficacy of the enzymatic systems of detoxification both in the tumor itself and in the surrounding tissues
Liver cytochrome P450 (CYP)-hydroxylation system is involved in the metabolism of polyunsaturated fatty acids (PUFAs), which oxidation leads to the formation of hydroxylated and epoxy derivatives of fatty acids
The animals were divided into the following groups: I – control II – rats with transplanted Guerin’s carcinoma; III – tumorbearing rats daily administered with ω-3 PUFAs
Summary
The susceptibility of transformed malignized cells to the action of cytostatics is largely determined by the functional efficacy of the enzymatic systems of detoxification both in the tumor itself and in the surrounding tissues. Liver CYP-hydroxylation system is involved in the metabolism of PUFAs, which oxidation leads to the formation of hydroxylated and epoxy derivatives of fatty acids. The metabolism of vitamin D in the body is provided by the functioning of a number of CYP isoforms (CYP2R1, CYP27A1, CYP27B1) [6], which ensure the formation of active metabolites (25OHD, 1,25 (OH) D). Inactivation of the latter is mediated by the action of catabolic CYP – CYP24A1 [7]. The purpose of the study was to elucidate the effects of separate and combined action of ω-3 PUFAs and vitamin D3 on the function of liver microsomal CYP-hydroxylation system in rats with transplanted Guerin’s carcinoma
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