LIVER CIRRHOSIS - STATISTICAL ANALYSIS DATA IN A 5 YEAR PERIOD IN PRILEP, REPUBLIC OF NORTH MACEDONIA

Jihe Zhu,Kristina Kozovska,Blagica Arsovska

doi:10.29121/granthaalayah.v8.i3.2020.171

Jihe Zhu, Kristina Kozovska + Show 1 more

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https://doi.org/10.29121/granthaalayah.v8.i3.2020.171

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Abstract

Liver cirrhosis is defined as a diffuse process, which is characterized by fibrosis and the conversion of normal liver architecture to abnormal nodules. For the purposes of this paper was used data from the Institute for Public Health in Prilep, Republic of North Macedonia in the period of 2014 to 2018. The data were analyzed and processed epidemiologically, descriptively and statistically. The total number of hospitalized patients in the analyzed period is 107 patients. The highest number of cases was registered in 2015 with 31 patients ie 29% and the lowest number in 2018 with 9 patients or 8%. According to gender, cirrhosis affected men more - 79 patients (74%) than women - 28 patients (26%). According to the age structure, the most of the cases were from 55 to 64 years old – 55 patients (51%). According to the etiological distribution, alcohol is the main cause of cirrhosis in Prilep region - 59 cases (55%). According to the hospitalization ie the number of hospital days, over a period of 5 years the number of hospital days is 432. In other patients the exact cause of cirrhosis has not been established. Analysis shows that the risk and severity of liver complications endanger life and quality of life and increase morbidity and mortality.

Highlights

Liver cirrhosis is defined as a diffuse process, which is characterized by fibrosis and the conversion of normal liver architecture to abnormal nodules
From the results shown in table 4 it can be noticed that alcoholic cirrhosis is present in 55%, while the unknown cirrhosis is present in 45%
According to the analysis it can be concluded that the risk and severity of liver complications endanger life and quality of life, as well as increase morbidity and mortality

Summary

Introduction

Liver cirrhosis is defined as a diffuse process, which is characterized by fibrosis and the conversion of normal liver architecture to abnormal nodules. Latent cirrhosis is detected by accident without any complications, but which has clinical features and/or biochemical changes. It is defined as manifested cirrhosis when it has subjective symptoms as a result of the two underlying syndromes - portal hypertension and liver failure. At the stage of decompensation, the clinical symptoms of advanced liver disease develop and are manifested as fatigue, weakness, weight loss, sub fibrillar fever, icterus, ascites, skin changes, endocrine changes, hepatic fever, hemorrhagic tendency, portal hypertension, hepatic encephalopathy and hepatomegaly. The goals of treatment are to slow down the progression of scar tissue in the liver and prevent or treat symptoms and complications of cirrhosis. Complications in liver cirrhosis are the result of portal hypertension, liver failure or a combination of both. The main consequences of portal hypertension include: ascites, varicose veins, hepatic encephalopathy, hepato-pulmonary hypertension, hepatocellular carcinoma, hepato-renal syndrome, spontaneous bacterial peritonitis and coagulation disorders. [1-6]

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Conclusion