Liver Cirrhosis, Etiology and Clinical Characteristics Disparities Among Minority Population.

Muhammad Abu Tailakh,Asia Estis-Deaton,Naim Abu-Freha,David Yardni,Ohad Etzion,Alexander Fich,Liat Poupko,Najwan Kayyal,Ali Alsana

doi:10.1007/s10903-021-01263-y

Muhammad Abu Tailakh, Asia Estis-Deaton + Show 7 more

Open Access

https://doi.org/10.1007/s10903-021-01263-y

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Abstract

Liver cirrhosis (LC) is a common disease with varied primary causes and ethnic disparities. Clinical characteristics and outcomes of Arab Bedouin (AB) and Jewish patients with LC were retrospective collected and compared. We included 1048 patients, 95 (9%) Arab Bedouin and 953 (91%) Jewish patients. The incidence of cirrhosis was much lower among AB. Age at diagnosis was 47 ± 18years among Bedouins compared to 61 ± 13years (p < 0.001) among Jews. The most frequent causes of cirrhosis among Bedouin patients were fatty liver 21.1%, cryptogenic 20%, hepatitis B 17.9% and autoimmune hepatitis 15.8%, while hepatitis C (39.2%), fatty liver (17.2%) and alcoholic liver disease (14.4%) were most common among Jewish patients. An all-cause mortality of 48.4% was observed in AB patients compared to 66.4% in Jewish patients (p < 0.001). Significant disparities regarding incidence, clinical characteristics and outcomes of cirrhosis among Arab Bedouin compared with Jewish population were found.

Highlights

Liver cirrhosis is a progressive scarring of liver tissue that occurs in advanced stages of chronic liver disease and is associated with several complications, including hepatocellular carcinoma (HCC) and mortality[1].There are several causes of cirrhosis, some important ones being autoimmune, viral, metabolic, toxic, and cryptogenic etiologies
An all-cause mortality of 41.8% was found in Arabs patients, compared to 63.4% in Jewish patients (p
We calculated the incidence of liver cirrhosis in the Arabs and Jewish populations between the years 2002 and 2016

Summary

Introduction

Liver cirrhosis is a progressive scarring of liver tissue that occurs in advanced stages of chronic liver disease and is associated with several complications, including hepatocellular carcinoma (HCC) and mortality[1].There are several causes of cirrhosis, some important ones being autoimmune, viral, metabolic, toxic, and cryptogenic etiologies (with no obvious cause). Liver cirrhosis is a progressive scarring of liver tissue that occurs in advanced stages of chronic liver disease and is associated with several complications, including hepatocellular carcinoma (HCC) and mortality[1]. Alcoholic liver disease is one of the most common causes of liver cirrhosis worldwide. In the Middle East, liver cirrhosis is still one of the top four causes of mortality [3]. With the highest prevalence of hepatitis C worldwide, suffers from a high prevalence of cirrhosis complications and mortality, according to a recently published study[4,5,6].In addition to the aforementioned etiologies, nonalcoholic fatty liver disease (NAFLD) may be a significant source of cirrhosis. Liver cirrhosis (LC) is a common disease with varied primary causes and ethnic disparities. We aimed to determine the frequency, clinical characteristics, and outcomes of liver cirrhosis among the Arabs population in southern Israel

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