Abstract
Proliferation of liver cells was studied in inbred single and parabiotic rats following ligation of the common bile duct. Thymidine-H 3 and autoradiographs were used to detect and quantitate nuclei synthesizing deoxyribonucleic acid. Common duct obstruction in a rat joined to a normal rat resulted in less liver cell degeneration and necrosis, less liver cell proliferation, and less elevation of the total serum bilirubin than in single rats with obstruction. The nonoperated partner exhibited slight elevation of serum bilirubin, no consistent change in hepatic thymidine-H 3 uptake, and no change in hepatic cell mitosis. It is suggested that liver cell proliferation following common bile duct obstruction is due to damage to liver cells by mechanical factors, together with the effects of retention of bilirubin and/or other components of bile, and this effect is not transmissible to parabiotic rats.
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