Abstract
THE MOST recent theories concerning the causative factors in experimental renal hypertension and their interrelationships may be stated as follows: 1. Renin, a protein-like substance, is formed in excessive amounts by an ischemic or anoxemic renal parenchyma. Hypertensinogen, the precursor of hypertensin, is a substance of the alpha-globulin fraction of the plasma which has been demonstrated to be formed in the liver and has a specificity for reacting with renin, produced in the kidney, to form hypertensin, the vasopressor substance. 2. The existence of a hitherto undescribed homeostatic system for the regulation of the peripheral circulation has been disclosed in studies by Shorr, Zweifach and Furchgott. 1 This system is made up of two components, one of hepatic (V. D. M.), the other of renal origin (V. E. M.). Evidence of the presence of such a circulatory homeostatic system, its mode and sites of origin, and the manner in which
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