Abstract
Chlorinated hydrocarbons are a highly toxic, ubiquitous class of environmental toxins of which 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic. PCB pyrolysates contain a complex mixture of these chemicals and have been shown to produce extensive alterations in the liver of guinea pig hepatocytes, including proliferated smooth endoplasmic reticulum (SER), concentric membrane arrays (CMA) which are a condensation of proliferated SER, and cytoplasmic vacuoles. A mechanism of membrane excretion into the bile canaliculi and sinusoids has been proposed to account for these alterations and their relationship to each other. This report demonstrates the proposed mechanism for a purified compound (TCDD) fed continuously for 90 days and further elucidates the role of the cytoplasmic vacuoles which are observed for dose levels at which no other alteration is present.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Proceedings, annual meeting, Electron Microscopy Society of America
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.