Abstract
Introduction: Deep burn injuries lead to dermal damage that impairs the ability of the skin to heal and regenerate on its own. Skin autografting is considered the current gold standard of care, but lack of patient’s own donor skin may require the temporary use of skin substitutes to promote wound healing, reduce pain, and prevent infection and abnormal scarring. These alternatives include donor skin allograft, xenograft, cultured epithelial cells and biosynthetic skin substitutes. Skin allograft is the use of skin from a genetically non-identical member of the same species as the recipient. Human deceased or live donor skin allografts represent a suitable and much used temporizing option for skin cover following severe burn injury until autografting is possible or re-harvesting of donor sites becomes available. Disadvantages of its use include the limited abundance and availability of donors, possible transmission of disease, the eventual rejection by the host and its handling, storing, transporting and associated costs of provision. Methods: Between August 2010 and August 2014, five patients underwent live skin allografting without medical immunosuppresion. All patients had deep severe burns of more than 40% burn surface area. 3 skin donors were patients’ mothers while 2 were brothers. Results: Three patients had complete healing not requiring skin autografting. One patient had hyper acute rejection and another had normal rejection and underwent secondary auto grafting. Conclusion: Live skin allografting is a useful skin substitute for severely burnt patients in resource limited areasKeywords: Burns, Allograft, Immunosuppresion, Family Donor
Highlights
Deep burn injuries lead to dermal damage that impairs the ability of the skin to heal and regenerate on its own
To be more than just a dressing, a biologic skin substitute should in some way be incorporated into the healing wound as happens with allografts and xenografts [2]
Five patients underwent live skin allografting between August 2010 and August 2014
Summary
The gold standard for burn wound coverage remains the autologous split-thickness skin graft. To be more than just a dressing, a biologic skin substitute should in some way be incorporated into the healing wound as happens with allografts and xenografts [2]. Skin from a live donor does not require complex preparation or preservation It can be used immediately after harvesting and provides a ready source of skin substitute. 2016 Volume 13 Issue 2 77 related to the patient the lesser the immunological rejection process [6] Both allografts and xenografts are biologic dressings only, are rejected by the patient’s immune system, and need to be removed prior to definitive wound treatment or skin grafting. Such burn patients will have rejection of the allografts delayed up to several weeks [18] This phenomenon will obviate the need to use immunosuppressive drugs in severely burnt patients.
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