Abstract
As waiting lists for lung transplantation are ever increasing, the number of organ donors is not able to keep pace with it. Living donor lobar lung transplantation is a source of organs which could be lifesaving in end-stage lung disease patients who cannot wait for cadaveric organs due to deteriorating lung function and clinical condition. Two young women with end stage cystic fibrosis received lobes from their relatives and an altruistic friend. They are surviving for more than 12 and 14 years with good lung functions.
Highlights
Living donor lobar lung transplantation (LDLLT) is performed as a life-saving procedure for critically ill patients who are unlikely to survive the long wait for cadaveric lungs
Immunosuppression protocol in LDLLT was similar to cadaveric donor lung transplantation, consisting of tacrolimus, mycophenolate mofetil and prednisolone and was started in the patient on the day of transplantation
The patients had cystic fibrosis and had rapid deterioration of their lung function which left us without any choice but to offer them option of LDLLT with relatives as donors
Summary
Living donor lobar lung transplantation (LDLLT) is performed as a life-saving procedure for critically ill patients who are unlikely to survive the long wait for cadaveric lungs. Recipient was weaned off ventilator in 48 hours, but had slow recovery and long intensive care unit stay due to infection with Pseudomonas, persistent pleural effusions, renal failure needing intermittent hemofiltration for a month and early rejection requiring re-intubation and methyl prednisolone pulse. She was discharged home 3 months after surgery and over another 6 moths her lung functions and exercise tolerance kept improving steadily. Case 2 Another woman of 34 years with cystic fibrosis related end stage lung disease had complaints of cough, haemoptysis, dyspnoea, early fatigue and was requiring nocturnal oxygen therapy Her clinical condition and lung function deteriorated rapidly following several repeated bouts of respiratory infections. Post-operative period was uneventful for both the donors, the friend was discharged on 5th while the mother on 7th day
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