Abstract
Steric stabilization of cationic lipid-DNA (CL-DNA) complexes is required for their use in vivo, but PEGylation (PEG; polyethylene glycol) of CL-DNA complexes reduces their efficacy as gene delivery vectors in vitro [1]. One approach to improving gene delivery with PEGylated CL-DNA nanoparticles is to covalently attach a targeting peptide at the distal end of PEG. We have developed PEGylated CL-DNA nanoparticles with an RGD or iRGD motif present at the distal end of PEG2000 and studied their efficacy and mechanism of entry in vitro.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
