Abstract
This contribution provides an overview of our work on modelling biological processes focussing on the example of programmed cell death, also called apoptosis. Apoptosis is a molecular programme present in all cells of multi-cellular organisms. It is crucial during development and for cell homoeostasis in the adult. Misregulation is implicated in severe diseases. We review an ordinary differential equation model describing core processes of apoptosis signalling and the idea of viewing the life and death decision as a bistable system. Then, we show how small differences in model parameters can give rise to observed population heterogeneities. Employing a new conceptional modelling framework, we further show how a single model can describe a population and how stable steady states then translate into invariant sets employing a local notion of stability.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
