Abstract
The safety and effectiveness of transseptal transcatheter mitral valve replacement (TMVR) is being evaluated in clinical trials targeting patients with mitral regurgitation at a high surgical risk or unfavorable anatomy for edge-to-edge repair. Severe mitral leaflet and annular calcification (MAC) may be associated with incomplete expansion of self-expanding prostheses or trauma, including catastrophic annular rupture, following balloon-expandable valve implantation.
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