Abstract
Engineered gold nanostructured arrays with feature separation in the sub-10-nm range werefabricated and used for highly sensitive surface enhanced Raman scattering (SERS)detection of biomarkers. Nanostructuring is achieved by combining electron beamlithography with the so-called shadow evaporation technique which involves a two-step Auvapor deposition through a suspended Ge mask while the substrate is tilted in oppositedirections. This results in a regular triangular surface pattern with extremely small gapdistances that allow positive enhancement of the local electric fields by enablingimprovements in the electromagnetic coupling between adjacent nanoparticles. Theresulting SERS active surfaces are suitable for the realization of reference procedures forquantifying marker molecules like urea or creatinine at physiologically relevantconcentrations.
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