Abstract
Received October 18, 2000; revised March 2, 2001; accepted March 15, 2001. From the University of Virginia, School of Medicine, RoanokeSalem Program and the Veterans Affairs Medical Center, Salem, Virginia. Address reprint requests to Dr. Rifai, VAMC, Medicine/Psychiatry 116A7, Salem, Virginia 24153. Copyright 2001 The Academy of Psychosomatic Medicine. Lithium remains a first-line treatment for acute manic states and bipolar affective disorders despite the introduction of newer alternative effective treatments. Lithium therapy, however, is associated with a variety of side effects. Although thyroid dysfunction is the most widely recognized endocrine side effect of lithium therapy, hypercalcemia and more rarely a biochemical picture resembling primary hyperparathyroidism may also develop. Recognition of this less common, but potentially life-threatening side effect, is important as an increasing number of patients are receiving long-term lithium therapy. The following case illustrates the potential impact of lithium on parathyroid function.
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