Abstract
Cultured human neuroblastoma cell lines were tested for the action potential sodium ionophore utilizing the Li + ion rather than the 22Na + ion. The cell lines studied included CHP-134, CHP-100, CHP-126, CHP-212 and LA-N-1. Veratridine-dependent uptake of Li + and 22Na + and its inhibition by tetrodotoxin implies the presence of the action-potential sodium ionophore. CHP-165, and undifferentiated tumor and RAJI a lymphoblast had no veratridine-dependent Li + uptake. Thus, veratridine-dependent Li + uptake provides a convenient means of assaying human neural cells for the action-potential sodium ionophore without the use of the radioactive Na + ion.
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