Abstract
The effect of various concentrations of lithium sulfate on human erythrocytes in vitro has been studied. It has been shown that the effect of lithium salt in maximum pharmacological and toxic concentrations on cells leads to a modification of the physicochemical state of membrane-bound proteins and lipids. It was found that in human erythrocytes exposed to lithium ions, there is a decrease in the activity of membrane-bound acetylcholinesterase and methgemoglobin reductase, as well as a change in the microviscosity of the lipid bilayer of membranes. The results obtained can be used to create a cell test system for assessing the toxicity of lithium compounds.
Highlights
The effect of various concentrations of lithium sulfate on human erythrocytes in vitro has been studied
First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: dissociation from clinical response to lithium or quetiapine / R
Bagatolli // Fluorescent Methods to Study Biological Membranes / ed
Summary
The effect of various concentrations of lithium sulfate on human erythrocytes in vitro has been studied. Нами проведена серия экспериментов по изучению активности мембраносвязанных ферментов (АХЭ и метгемоглобинредуктазы) в эритроцитах, подвергшихся воздействию сульфата лития 1. Зависимости Лайнуивера–Берка для ацетилхолинэстеразы в мембранах, изолированных из эритроцитов до и после воздействия различных концентраций сульфата лития.
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