Abstract
The effect of lithium (Li) treatment on serotonin 1 (5-HT 1) receptors and 5-HT-sensitive adenylate cyclase (ACase) activity in rat hippocampus was studied. [ 3H]5-HT binding to 5-HT 1 receptors was decreased after either subacute (5 days) or chronic (3 weeks) treatment. In contrast, 5-HT-stimulated [ 3H] cyclic adenosine monophosphate ([ 3H]cAMP) formation was unchanged after 5 days of Li treatment, but was increased after 3 weeks of treatment. There was no difference in the inhibitory effects of guanosine triphosphate (GTP) on [ 3H]5-HT binding between the subacute Li and control groups. In addition, [ 3H]cAMP formation induced by GTP was not changed in the subacute group, whereas chronic treatment decreased it. These results suggested that chronic Li treatment caused the facilitation of 5-HT-sensitive ACase activity in spite of a decrease in the density of 5-HT, receptors in the hippocampus. The enhancement of the coupling between receptor and ACase seemed not to be involved in these Li effects.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
